Telescope: Characterization of the retrotranscriptome by accurate estimation of transposable element expression

Publishing date: 2019-10-17

Published on: PLOS Computational Biology

summary: Almost half of the human genome is composed of transposable elements (TEs), but their contribution to the transcriptome, their cell-type specific expression patterns, and their role in disease remains poorly understood. Recent studies have found many elements to be actively expressed and involved in key cellular processes. The authors also showed that Telescope performed better than other methods currently used to determine TE expression. The use of this computational tool to examine new and existing RNA-seq data sets may lead to new understanding of the roles of TEs in health and disease.

authors: Matthew L. Bendall, Miguel de Mulder, Luis Pedro Iñiguez, Aarón Lecanda-Sánchez, Marcos Pérez-Losada, Mario A. Ostrowski, R. Brad Jones, Lubbertus C. F. Mulder, Gustavo Reyes-Terán, Keith A. Crandall, Christopher E. Ormsby, Douglas F. Nixon

link to paper: 10.1371/journal.pcbi.1006453

Icons made by catkuro from www.flaticon.com