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Open sourcing bioinstruments

Publishing date: 2019-02-01 Published on: Bits of DNA summary: While open sourcing has become de rigueur in genomics dry labs, wet labs remain beholden to commercial instrument providers that rarely open source hardware or software, and impose draconian restrictions on instrument use and modification.

Open-source automated chemical vapor deposition system for the production of two- dimensional nanomaterials

Publishing date: 2019-02-01 Published on: PLOS ONE summary: The study of two- dimensional (2D) materials is a rapidly growing area within nanomaterials research. However, the high equipment costs, which include the processing systems necessary for creating these materials, can be a barrier to entry for some researchers interested in studying these novel materials.

Open-Source Multiparametric Optocardiography

Publishing date: 2019-02-01 Published on: Scientific Reports summary: None authors: None link to paper: https://www.nature.com/articles/s41598-018-36809-y Icons made by catkuro from www.flaticon.com

optoPAD: a closed-loop optogenetics system to study the circuit basis of feeding behaviors

Publishing date: 2019-02-01 Published on: bioRxiv summary: The regulation of feeding plays a key role in determining the fitness of animals through its impact on nutrition. Elucidating the circuit basis of feeding and related behaviors is an important goal in neuroscience.

VasoTracker, a low-cost and open source pressure myograph system for vascular physiology

Publishing date: 2019-02-01 Published on: Physiology | Frontiers summary: None authors: Penelope F. Lawton, Matthew D. Lee, Christopher D. Saunter, John M. Girkin1, John G. McCarron and Calum Wilson link to paper: https://www.

Bayesian multiple logistic regression for case-control GWAS

Publishing date: 2019-01-17 Published on: PLOS Genetics summary: Genetic variants in genome-wide association studies (GWAS) are tested for disease association mostly using simple regression, one variant at a time. Standard approaches to improve power in detecting disease-associated SNPs use multiple regression with Bayesian variable selection in which a sparsity-enforcing prior on effect sizes is used to avoid overtraining and all effect sizes are integrated out for posterior inference.

Context-explorer: Analysis of spatially organized protein expression in high-throughput screens

Publishing date: 2019-01-17 Published on: PLOS Computational Biology summary: Channel Editor’s Summary: To many, open source software means “free to use”, and to others it might mean “I can see and re-use the code freely”.

Enabling precision medicine via standard communication of HTS provenance, analysis, and results

Publishing date: 2019-01-17 Published on: PLOS Biology summary: A personalized approach based on a patient’s or pathogen’s unique genomic sequence is the foundation of precision medicine. Genomic findings must be robust and reproducible, and experimental data capture should adhere to findable, accessible, interoperable, and reusable (FAIR) guiding principles.

Julia language co-creators win James H. Wilkinson Prize for Numerical Software

Publishing date: 2019-01-17 Published on: MIT News summary: Three co-creators of the MIT-incubated Julia programming language are the recipients of the 2019 James H. Wilkinson Prize for Numerical Software. The prize will be awarded to Bezanson, Karpinski, and Shah “for the creation of Julia, an innovative environment for the creation of high-performance tools that enable the analysis and solution of computational science problems.

Validating quantum-classical programming models with tensor network simulations

Publishing date: 2019-01-17 Published on: PLOS ONE summary: The exploration of hybrid quantum-classical algorithms and programming models on noisy near-term quantum hardware has begun. As hybrid programs scale towards classical intractability, validation and benchmarking are critical to understanding the utility of the hybrid computational model.